Substituted imidazo 1,5-A!pyridine derivatives and

专利名称：Substituted imidazo 1,5-A!pyridine

derivatives and other substituted bicyclicderivatives, useful as aromatase inhibitors

发明人：Leslie J. Browne申请号：US06/825830申请日：19860204公开号：US04728645A公开日：19880301

摘要：Disclosed are compounds of formula I ##STR1## wherein R.sub.1 representshydrogen, lower alkyl, substituted lower alkyl, nitro, halogen, free, etherified oresterified hydroxy, free, etherified, oxidized etherified or esterified mercapto,unsubstituted, mono- or disubstituted amino, ammonio, free or functionally modifiedsulfo, free or functionally modified formyl, C.sub.2 -C.sub.20 -acyl, cyano, free or

functionally modified carboxy; and R.sub.2 represents hydrogen, lower alkyl, substitutedlower alkyl, halogen; free, etherified or esterified hydroxy; free, etherified, oxidizedetherified or esterified mercapto; free or functionally modified carboxy, or acyl; the 7,8-dihydro derivatives thereof; and compounds of the formula I* ##STR2## wherein ndenotes 0, 1, 2, 3 or 4, and R.sub.1 and R.sub.2 are as defined above under formula I andsalts thereof; e.g. as aromatase inhibitors; pharmaceutical compositions containing thesecompounds; the use of these compounds for the treatment of conditions responsive toe.g. aromatase inhibition in mammals; processes and intermediates for preparing thesecompounds.

申请人：CIBA-GEIGY CORPORATION

代理人：Norbert Gruenfeld

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